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Probiotics and enhanced immune system function - Activated Probiotics

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IMMUNE HEALTH

Probiotics and enhanced immune system function

BY Ben Makeham May 8, 2020

The gastrointestinal system is home to 70% of the body’s immune cells.

The gut microbiota and its metabolites, particularly short chain fatty acids such as butyrate, interact with the intestinal epithelial cells and the underlying immune cells.

As a result, bacteria-derived metabolites are thought to trigger a cascade of changes in immune cell phenotypes and cytokine secretion which supports enhanced immune function.

A healthy gut microbiota and various strains of probiotics enhance immune system function via various different pathways, and have been observed to:

Induce and activate dendritic cells and macrophages
Directly activate natural killer T cells
Increase IgA production by B-cells

Specific probiotic strains may therefore have the ability to influence the activity of both innate and adaptive immune cells in the gastrointestinal system, altering systemic immune function when immune cells enter circulation and travel across the body. Strains with clinically proven immune enhancing effects include Lactobacillus rhamnosus GG, Lactobacillus plantarum HEAL 9 and Lactobacillus paracasei 8700:2, found across our Biome DailyTM, Biome Daily KidsTM and Biome AdvancedTM Probiotics. Find out more about our probiotics for clinically proven immune protection here (download button, link etc.)

References

  • Berggren A, Lazou Ahrén I, Larsson N, Önning G. Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections. Eur J Nutr [Internet]. 2011 Apr 28;50(3):203–10.
  • Busch R, Gruenwald J, Dudek S. Randomized, double blind and placebo controlled study using a combination of two probiotic Lactobacilli to alleviate symptoms and frequency of common cold. Food Nutr Sci [Internet]. 2013;04(11):13–20
  • Frei R, Akdis M, O’Mahony L. Prebiotics, probiotics, synbiotics, and the immune system. Curr Opin Gastroenterol [Internet]. 2015 Mar;31(2):153–8.
  • Laursen RP, Hojsak I. Probiotics for respiratory tract infections in children attending day care centers—a systematic review. Eur J Pediatr [Internet]. 2018 Jul 12;177(7):979–94.
  • Liu S, Hu P, Du X, Zhou T, Pei X. Lactobacillus rhamnosus GG supplementation for preventing respiratory infections in children: A Meta-analysis of Randomized, Placebo-controlled Trials. Indian Pediatr [Internet]. 2013 Apr 25;50(4):377–81.

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