How the gut-skin axis influences acne - Activated Probiotics



How the gut-skin axis influences acne


A healthy gut microbiome, due to its ability to reduce skin inflammation and inhibit the growth of pro-inflammatory bacteria in the skin, can play a vital role in helping to protect us against acne. Activated Probiotics’ newest product, Biome Acne™, has been clinically proven to improve the gut-skin axis and reduce the symptoms of acne. Learn more about Biome Acne™ Probiotic and how the gut-skin axis influences acne in our latest blog post.

Is acne caused by inflammation?

As with many other health conditions, we’re now beginning to understand that the main cause of acne might be inflammation.
Inflammation in the hair follicles and associated oil glands in the skin leads to increased secretion of oil, blocking follicles and creating an environment that Cutibacterium acnes bacteria loves to grow in. Immune cells in the skin react to this overgrowth of bacteria by launching an inflammatory response, worsening the problem. Together, these processes create pimples and lesions associated with acne.
There can be many factors which increase inflammation and oil production in the hair follicles and kick-start this process, but the balance of microorganisms that live within the gut is a particularly important one due to the gut-skin axis.

The gut-skin axis and the gut microbiome

The health of the gut microbiota is thought to influence skin health and the development of acne through its effects on the immune system and the levels of inflammation it is programmed to create. A healthy gut microbiome can reduce inflammation produced by immune cells in the gut, with these effects transferred to the immune cells in the skin through circulation and chemical messaging (2).
The gut microbiome also interacts with the skin microbiome through the production of nutrient-like substances which enter circulation and accumulate in the skin, some of which have antibacterial properties that can keep C. acnes bacteria at bay (2,3).
Studies on the gut microbiome of people with acne have demonstrated low microbial diversity and unfavourable compositions, and these differences are thought to be contributing to inflammatory immune responses and the symptoms of acne (2).
As a healthy gut microbiome may help to prevent or reduce the symptoms of acne, improving the gut-skin axis through the use of specific probiotics is growing in interest.

Biome Acne™ Probiotic

Biome Acne™ Probiotic is Activated Probiotics’ latest condition-specific probiotic that has been clinically proven to reduce the symptoms of acne.
The specific beneficial probiotic bacteria within Biome Acne™ Probiotic have been studied for their ability to improve the symptoms of acne via their effects within the gut, including beneficial interactions with the immune system and production of antimicrobial substances (5). In a human clinical trial, the probiotic strains within Biome Acne™ significantly improved the symptoms of acne, reduced skin redness, and improved the composition of the skin microbiome (4).
Beneficial bacteria, due to their ability to interact with the creators of inflammation (immune cells) and reduce the growth of pro-inflammatory bacteria in the skin, can play a vital role in protecting us from acne. Using clinically-trialed probiotic strains such as Biome Acne™ Probiotic to improve the gut-skin axis is one way which may help to reduce the symptoms of acne and improve the skin microbiome.


1. Tanghetti, Emil. A. (2013). The role of inflammation in the pathology of acne. Journal of Clinical and Aesthetic Dermatology, 6(9), 16–24.
2. Lee, Byun, & Kim. (2019). Potential Role of the Microbiome in Acne: A Comprehensive Review. Journal of Clinical Medicine, 8(7)
3. Dréno, B., Dagnelie, M. A., Khammari, A., & Corvec, S. (2020). The Skin Microbiome: A New Actor in Inflammatory Acne. American journal of clinical dermatology, 21(Suppl 1), 18–24.
4. Rinaldi, F., Marotta, L., Mascolo, A., Amoruso, A., Pane, M., Giuliani, G., & Pinto, D. (2022). Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement. Dermatology and Therapy.
5. Deidda F, Amoruso A, Nicola S, Graziano T, Pane M, Mogna L. New Approach in Acne Therapy A Specific Bacteriocin Activity and a Targeted Anti IL-8 Property in Just 1 Probiotic Strain, the L. salivarius LS03. J Clin Gastroenterol. 2018 Nov 1;52:S78–81.




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